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Reproductive studies in rats and mice have shown delayed date of delivery, prolonged duration of labour and decreased pup survival at dosages approximately 50 times greater than the maximum recommended dosage for humans based onmg/kg. There was no effect on the fertility of rats treated with amlodipine males for 64 days and what is amlodipine besylate 5 mg used fors 14 days prior to mating at doses up to 10 mg/kg/day 8 times* the maximum recommended human dose of 10 mg on a mg/m2 basis In another rat study in which male rats were treated with amlodipine besilate for 30 days at a dose comparable with the human dose based on mg/kg, decreased plasma follicle-stimulating hormone and testosterone were found as well as decreases in sperm density and in the number of mature spermatids and Sertoli cells.Daily dosages exceeding 10 mg of amlodipine given in fixed combination with 40 mg of olmesartan medoxomil are not recommended by the manufacturer.

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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use amlodipine only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Rats and mice treated with amlodipine maleate in the diet for up to two years, at concentrations calculated to provide daily dosage levels of.

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High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly.- PMID.

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Lithium Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving ACE inhibitors during therapy with lithium.

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Upon re-initiation of insulin there was an immediateimprovement in mean arterial blood pressures suggesting that HDI therapy mayplay a significant role in CCB overdose.The combination of 2.

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Rats and mice treated with amlodipine maleate in the diet for up to two years, at concentrations calculated to provide daily dosage levels of 0. mg, 1.This helps lower blood pressure, reduce heart pain angina treat abnormal heart rhythms such as atrial fibrillation and reduce your risk of stroke.

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The largest and most consistent cardiovascular outcome benefit cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit.A study found subjects with diastolic blood pressure above 90 mm Hg at baseline had a fall of 8 mm Hg on terazosin Debruyne et al.

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