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Ondansetron
Clinical data
Trade namesZofran, Ondisolv, others
AHFS/Drugs.comMonograph
MedlinePlusa601209
Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationBy mouth, rectal, IV, IM
ATC codeA04AA01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability~60%
Protein binding70–76%
MetabolismLiver (CYP3A4, CYP1A2, CYP2D6)
Elimination half-life5.7 hours
ExcretionKidney

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Because ondansetron is metabolized by ondansetron 8mg tablet cytochrome P-450 drug-metabolizing enzymes CYP3A4, CYP2D6, CYP1A2 inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron see Clinical Pharmacology 12. Ministry of Health and Long-Term Care Ontario Public Drug ... Placing a medication in a cool place, such as a refrigerator, will help a drug remain potent for many years.

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Si tiene problemas con sus niveles de sales en sangre, como potasio, sodio o magnesio.5 mg/kg of intravenous ondansetron every 4 hours for 3 que es ondansetron 8 mg would be expected to achieve a systemic exposure AUC consistent with the exposure achieved in previous pediatric trials in cancer patients 4 to 18 years at similar doses. In a trial que es ondansetron 8 mg 21 pediatric patients 3 to 12 years who were undergoing surgery requiring anesthesia for a duration of 45 minutes to 2 hours, a single intravenous dose of ondansetron, 2 mg 3 to 7 years or 4 mg 8 to 12 years was administered immediately prior to anesthesia induction.

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15 mg/kg, 0. 5 mg/kg, and 0.5 mg/kg given 3 times dailycalculated on the basis of body surface area have not revealed evidence of harm to the fetus.

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Ondansetron generally is well tolerated. Most adverse effects reported in clinical trials have been mild to moderate in severity.Tumor response to chemotherapy in the P-388 mouse leukemia model is not affected by ondansetron. In humans, carmustine, etoposide, and cisplatin do not affect the pharmacokinetics of ondansetron.

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The concomitant use of apomorphine with ondansetron is contraindicated based on ondansetron 8mg tablets of profound hypotension and loss of consciousness when apomorphine was administered with ondansetron.

Hypersensitivity reactions, including anaphylaxis and bronchospasm, have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists.Before using this ondansetron 8mg tablet, tell your doctor or pharmacist your medical history, especially of: irregular heartbeat, liver disease, stomach/intestinal problems e.

recent abdominal surgery, ileus, swelling Ondansetron may cause a condition that affects the heart rhythm QT prolongation QT prolongation can rarely cause serious rarely fatal fast/irregular heartbeat and other symptoms such as severe dizziness, fainting that need medical attention right away.

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Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.It is thought that systemic absorption is minimal and the risk to a fetus or que es ondansetron 8 mg is low.

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Based on this we calculated that enrollment of 133 ondansetron 8 mg corresponding to 80 RV or NoV positives would yield a power of 80% with two sided significance level of 95% Due to difficulties in recruiting children, we reached a number of 104 participants during the two-year study period. However, the proportion of children with AGE due to RV and NoV was higher than expected, with 86 children being RV or NoV positive.Drug manufacturers are required to stamp an expiration date on their products.

If your medicine has a use by or use before date instead of an expiration date, this usually ondansetron 8 mg that you shouldn't take the medicine after the end of the previous month.

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Ondansetron is used que es ondansetron 8 mg prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.

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You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm que es ondansetron 8 mg such as QT prolongation.Therefore, they have rather low value in treating gastric disorders in dogs and cats.

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Serotonergic Drugs e. SSRIs and SNRIs There have been post-marketing reports describing patients with serotonin syndrome including altered mental status, autonomic instability and neuromuscular abnormalities following the concomitant use of ondansetron and other serotonergic drugs including SSRIs and SNRIs see section 4.5-mg/kg doses was significantly more effective than placebo in preventing nausea and vomiting induced by cisplatin-based chemotherapy.

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