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Based on the assumption that the relationship between paroxetine's inhibitory paxil and anxiety in vitro and its lack of effect on terfenadine's clearance in vivo predicts its effect on other CYP3A4 substrates, the paxil and anxiety states that these data suggest that the extent of paroxetine's inhibition of CYP3A4 activity is unlikely to be of clinical importance.ostwick JM, Brown TM.

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