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Loperamide
Clinical data
Pronunciation/ l oʊ ˈ p ɛr ə m aɪ d /
Trade namesImodium, others [1]
AHFS/Drugs.comMonograph
MedlinePlusa682280
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationBy mouth
ATC codeA07DA03 ( WHO ) A07DA05 ( WHO ) (oxide)
Legal status
Legal statusAU: S2 (Pharmacy only) CA : OTC UK: General sales list (GSL, OTC) US: OTC
Pharmacokinetic data
Bioavailability0.3%
Protein binding97%
MetabolismLiver (extensive)
Elimination half-life9–14 hours [2]
ExcretionFaeces (30–40%), urine (1%)

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Article citation: Drug Safety Update volume 11 issue 6; January 2018: 4. Published 9 January 2018. Related content. Loperamide (Imodium): ...

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2011 Aug; 2 319-23. doi.Full Text.

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564BiodegradationNot ready biodegradable0.Due to this very high first pass effects, plasma concentrations of unchanged drug remain extremely low.

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Additionally, hypoglycemia has been reported in cases of unintentional pediatric ingestion. One report detailed the case of an 11-month-old male who became hypoglycemic serum glucose concentration 17 mg/dL after unintentional methadone exposure.om. /health/imodium-opioid-addiction.

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To continue ordering a prescription, loperamide chloride click on the button below to update your credit card information.Cardiac toxicity, defined as syncope, chest pain, cardiac arrhythmia, cardiomegaly, tachycardia, or hypotension, in loperamide abuse is becoming frequent in the literature.

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The purpose of this study is to determine loperamide chloride trends in loperamide chloride loperamide abuse and misuse, Bhatti Z1, Norsworthy J1, Szombathy T1. Loperamide metabolite-induced cardiomyopathy and QTc prolongation.

Clin Toxicol Phila 2017 Aug; 7 659-661.The side effects listed below are not experienced by everyone who takes this medication.

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Taking loperamide and simethicone with certain other drugs may If you have an allergy to loperamide, simethicone, or any other part of loperamide and simethicone. If you are allergic to loperamide and simethicone; any part of loperamide and simethicone; or any other drugs, foods, or substances.And this is post-chemotherapy and abdominal radiation.

Step 1: The patient can take up to 8 Imodium per day.

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