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Spironolactone
Clinical data
Pronunciation/ ˌ s p aɪ r oʊ n oʊ ˈ l æ k t oʊ n / SPY -roh-noh- LAK -tone, [3] / ˌ s p ɪər oʊ n oʊ ˈ l æ k t oʊ n / SPEER -oh-noh- LAK -tone [4]
Trade namesAldactone, Spiractin, Verospiron, many others; combinations: Aldactazide (+HCTZ), Aldactide (+HFMZ), Aldactazine (+altizide), others
AHFS/Drugs.comMonograph
MedlinePlusa682627
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationBy mouth, [1] topical [2]
Drug classAntimineralocorticoid; Steroidal antiandrogen
ATC codeC03DA01 ( WHO )
Legal status
Legal statusUK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability60–90% [5] [6] [12]
Protein bindingSpironolactone: 88% (to albumin and AGP) [13] Canrenone: 99.2% (to albumin) [13]
MetabolismLiver, others: • Deacetylation via CES • S -Oxygenation via FOM • S -Methylation via TMT • Dethioacetylation • Hydroxylation via CYP3A4 • Lactone hydrolysis via PON3) [5] [6] [7] [8] [9] [10] [11]
Metabolites7α-TS, 7α-TMS, 6β-OH-7α-TMS, canrenone, others [5] [6] [14] (All three active) [15]
Elimination half-lifeSpironolactone: 1.4 hrs [5] 7α-TMS: 13.8 hours [5] 6β-OH-7α-TMS: 15.0 hrs [5] Canrenone: 16.5 hours [5]
ExcretionUrine, bile [6]

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Spironolactone synonyms goods:
  • Aldactacine 25 mg
  • Aldactazide 25 mg
  • Aldactazine 25 mg
  • Aldactide 100 mg
  • Aldazida 25 mg
  • Aldazide 100 mg
  • Aldoleo 25 mg
  • Aldonar 100 mg
  • Aldospirone 25 mg
  • Aldozone 25 mg
  • Alexan 25 mg
  • Alizar 100 mg
  • Almatol 25 mg
  • Alspiron 25 mg
  • Aporasnon 100 mg
  • Cardactona 100 mg
  • Cardiatone 25 mg
  • Carpiaton 25 mg
  • Diulactone 100 mg

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Consult your throat, practitioner, andor frequency for any health problem and alternative for spironolactone initiating any problems or alternative for spironolactone planning any problems in prescribed medications. Multimedia expires December 2020. That might catholic not replace the saliva of a substitute. Usually, Structured disclaims any other or other for your use of this information.

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Spironolactone properties
Pill name Spironolactone
Spironolactone all product namealdactacine, aldactazide, aldactazine, aldactide, aldazida, aldazide, aldoleo, aldonar, aldospirone, aldozone, alexan, alizar, almatol, alspiron, aporasnon, cardactona, cardiatone, carpiaton, diulactone, docspirochlor, docspirono, espimax, espirone, espironolactona, expal, flumach, furorese comp, hexalacton, huma-spiroton, jenaspiron, kespirona, lacalmin, lanx, laractone, letonal, macacy, merlactone, modulactone, nefrotone, noidouble, noractone, normital, novo-spiroton, novo-spirozine, novospiroton, osiren, osyrol, pilactone, pirolacton, practazin, practon, prilactone, rakudeen, rediun-e, sali-aldopur, spilactone, spiractin, spiresis, spiretic, spirix, spiro-ct, spirobene, spirobeta, spiroctan, spiroctazide, spirogamma, spirohexal, spirola, spirolacton, spirolang, spirolon, spiron, spirono, spironol, spironolacton, spironolactona, spironolactonum, spironolakton, spironolattone, spironone, spironothiazid, spirospare, spirotone, uractone, uractonum, urusonin, velactone, verospilactone, verospiron, vivitar, xenalon, youlactone
Active substancesaldactone
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